摘要
目的评估全身代谢因素对康柏西普治疗糖尿病黄斑水肿疗效的影响。方法回顾性分析25例(25只眼)玻璃体腔注射康柏西普治疗糖尿病黄斑水肿患者的临床资料,其中女性12例,男性13例,平均年龄(61.36±8.98)岁,观察最佳矫正视力(BCVA)(ETDRS视力表)、黄斑中心凹厚度(CST)、黄斑总容积(TMV)的变化及与同期相关的糖化血红蛋白、血脂、血肌酐、血尿素等全身代谢因素之间的关系。结果术前BCVA 22.70±3.30(字母数),CST(506.52±33.45)μm,TMV(13.95±0.53)mm^3。至术后1个月时,BCVA平均增加10.70±1.82(P<0.001),CST平均降低(137.48±33.61)μm(P<0.001),TMV平均减少(1.34±0.35)mm^3(P=0.001)。BCVA的提高与术前各代谢指标未显示有明显的相关性;术后1周及1个月CST的变化仅与三酰甘油呈负相关(r_(1周)=-0.601,P=0.002;r_(1个月)=-0.522,P=0.015),三酰甘油高,CST较基线下降更大;术后1周TMV的变化与三酰甘油呈负相关(r=-0.424,P=0.044),术后1个月TMV与三酰甘油水平无明显相关(r=-0.323,P=0.153),TMV变化与其他代谢指标未见明显相关性。结论玻璃体腔注射康柏西普能明显降低黄斑中心凹厚度,提高最佳矫正视力,血脂可能是影响康柏西普注射后黄斑中心凹厚度变化的代谢性因素。
OBJECTIVE To evaluate the role of systemic factors on outcomes of diabetic macular edema treated by conbercept injection. METHODS It was a retrospective study including 25 diabetic macular edema(DME) patients(25 eyes) treated with conbercept therapy. The study included 12 female and 13 male patients with a mean age of 61.36±8.98. The main outcome was indicated by change in best corrected visual acuity(BCVA), central subfield macular thickness(CST), and total macular volume(TMV); and their correlation with clinical findings(the serum hemoglobin A1 c values, serum lipid, creatinine, urea nitrogen) were analyzed. RESULTS Before treatment,result of BCVA, CST and TMV were 22.70 ±3.30 letters, 506.52 ±33.45 μm and 13.95 ±0.53 mm^3 respectively. One month after conbercept treatment, there was statistically significant improvement in BCVA(10.70 ±1.82 letters, P〈0.001) and statistically significant decrease in CST(-137.48 ±33.61 μm, P〈0.001) and TMV(-1.34±0.35 mm^3, P=0.001). The triglycerides values were found to be negatively correlated with the change in CST(r=-0.522, P=0.015).CONCLUSIONS The results of intravitreal conbercept injection for DME demonstrated beneficial effects on BCVA and decrease in CST. Serum lipids may impact the effects of conbercept therapy on CST improvement.
出处
《中国中医眼科杂志》
2017年第5期322-325,共4页
China Journal of Chinese Ophthalmology
基金
首都卫生发展科研专项重点攻关项目(2016-1-4181)
中国中医科学院自主选题(ZZ0808008)
关键词
糖尿病黄斑水肿
代谢因素
康柏西普
血管内皮生长因子
diabetic macular edema
metabolic parameters
conbercept
vascular endothelial growth factor