胎儿先天性心脏病与孕妇头发化学元素含量的关系

The relationship between fetal congenital heart disease and the content of chemical elements of hair in pregnant women

目的探讨胎儿先天性心脏病(CHD)与孕妇头发化学元素含量的关系。方法选择福建省妇幼保健院经超声心动图检查,诊断胎儿患CHD的孕妇72例为病例组;按年龄和孕周11配对的对照组72例。收集孕妇头发,用电感耦合等离子质谱法(ICP-MS)检测24种化学元素含量;用条件logistic回归分析胎儿CHD的危险因素及危险度。结果多因素分析表明,镁、硒、钡、锑和砷是CHD的危险因素,危险度分别是46.60、4.61、3.94、3.90和3.18。结论孕妇头发镁、硒、钡、锑和砷含量升高是胎儿CHD的危险因素。应重视围孕期孕妇的生活环境改善,减少危险因素暴露,以预防胎儿CHD。

Objective To explore investigate the relationship between fetal congenital heart disease（CHD）and the content of chemical elements of hair in pregnant women.Methods Totally 72 pregnant women with the baby suffered from CHD by echocardiography were selected as case group,and by using 1∶1 matched study,based on the age and gestational age,totally 72 normal pregnant women were collected as control group from Fujian Provincial Maternity and Children＇s Hospital.The hair samples of the women were collected and 24 kinds of chemical element contents were detected by inductively coupled plasma-mass spectrometry.And the risk factors and risk degree for CHD were analyzed by conditional logistic regression model.Results Magnesium,selenium,barium,antimony and arsenic were the risk factors for CHD by multiple factor conditional logistic regression model,the values for OR were 46.60,4.61,3.94,3.90 and 3.18 respectively.Conclusion The content raising of magnesium,selenium,barium,antimony and arsenic are the risk factors for fetal CHD.The living environment of pregnant women should be improved and the exposure of pathogenic chemical elements should be avoided for fetal CHD control and prevention.