摘要
NSD2也称为MMSET或者WHSC1,是NSD组蛋白甲基转移酶家族中的一员.组蛋白的甲基化修饰作为表观遗传学中重要的调控机制,在转录调控以及染色质重构等多种生物学过程中发挥重要作用.由t(4;14)(p16;q23)易位所导致的NSD2过表达与多发性骨髓瘤患者预后紧密相关.此外,在其他多种恶性肿瘤中也检测到NSD2的高表达.NSD2催化组蛋白的赖氨酸位点发生甲基化并通过参与多种蛋白的相互作用或对靶基因的调控而促使肿瘤的发生发展.NSD2及相关信号分子有望成为多种相关肿瘤的治疗靶点,深入探究NSD2的作用机制将促进相关靶向药物的发展,为多种NSD2相关肿瘤提供新的治疗方案.
Nuclear receptor binding SET domain-protein 2（NSD2）,also known as MMSET or WHSC1, is a member of the NSD family. Methylation of histone as an important regulatory mechanism in epigenetics plays an important role in transcriptional regulation and chromatin remodeling. The overexpression of NSD2, caused by t（4; 14）（p16; q23） translocation, is closely related to the prognosis of patients with multiple myeloma. In addition, high expression of NSD2 can be detected in many other malignant tumors. NSD2 catalyzes the methylation of the lysine sites of histone, and promotes the initiation and progression of tumors by participating in the interaction among multiple proteins or the regulation of target genes. NSD2 and related signal molecules are expected to be the targets for treatment of various related tumors. Elucidating the mechanism of NSD2 may promote the development of targeted drugs and provide new solutions for the treatment of various NSD2-related tumors.
出处
《世界华人消化杂志》
CAS
2017年第36期3218-3223,共6页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.81572413~~
关键词
NSD2
组蛋白甲基转移酶
靶向治疗
多发性骨髓瘤
Nuclear receptor binding SET domain-protein2
Histone methyltransferase
Targeted therapy
Multiplemyeloma
