髋部暂时性骨质疏松症发病机制研究进展

Research progress on pathogenesis of temporary osteoporosis in hip

髋关节暂时性骨质疏松症(transient osteoporosis of the hip,TOH)被归类为骨髓水肿综合征的一种。TOH既往研究不少,对其发病机制存在争议。近年来随着影像学、病理学、分子生物学等多学科的发展,研究发现该病发病机制较复杂且不明确,本文从神经源性、骨坏死、血管功能异常、软骨下骨折、遗传、区域性加速现象等方面对TOH的相关发病机制的研究进展进行了概括。

Transi ent osteoporosis of the hip（TOH） is classified as a type of bone marrow edema syndrome. TOH is lack of previous study and there is still controversy about his pathogenesis. In recent years,with the development of multi-discipline,such as imaging,pathology,molecular biology,the study has found that the pathological mechanism is complex,while its mechanism is still not clear,which need further research. This paper summarizes the research progress on the pathogenesis of TOH from neurogenic,osteonecrosis,abnormal vascular function,subchondral fracture,heredity and regional acceleration and son on.