胃肠安丸对功能性消化不良患者的临床观察

Clinical Observation on Weichang'an Pills in the Treatment of Functional Dyspepsia

目的探讨胃肠安丸对功能性消化不良患者的临床疗效。方法收集我院消化科门诊收治的功能性消化不良患者72例,随机分为对照组与试验组,各36例。对照组予以枸橼酸莫沙必利片5mg,3次/d;试验组在此基础上给予胃肠安丸0.08 g,3次/d,2组患者均用药7 d。治疗结束后比较2组患者临床疗效、症状积分、胃动素及生长抑素水平。结果治疗后2组症状及总积分降低,胃动素水平升高,生长抑素降低(P<0.05);与对照组相比,试验组临床总有效率较高,主要症状及总积分较低,胃动素水平较高,生长抑素较低(P<0.05)。结论胃肠安丸治疗功能性消化不良的疗效较确切,能显著改善患者消化不良症状,其作用机制可能与上调血清胃动素水平、降低血清生长抑素水平有关。

Objective To investigate the clinical effect of Weichangan pills in the treatment of functional dyspepsia. Methods 72 cases of functional dyspepsia patients were randomly divided into the control group and the study group, with 36 cases in each group.The control group received Mosapride Citrate 5 mg, tid, and the study group also received Weichangan pills 0.08 g, tid. 2 groups of patients were treated for 7 days. The clinical effect, symptom score, motilin and somatostatin levels were compared in 2 groups.Results The symptom scores and the total scores of the two groups decreased, levels of motilin of the two groups increased, and somatostatin of the two groups decreased（ P 0.05）. Comparing with the control group, the total effective rate of study group was higher, the main symptoms and the total scores were lower, levels of motilin were higher, and somatostatin were lower（ P 0.05）.Conclusion Weichangan pills in the treatment of functional dyspepsia is effective, can significantly improve the symptoms of dyspepsia, and its mechanism may be related to increased the levels of MTL and decrease serum SS.