摘要
目的考察三七川归颗粒方中药材水溶性成分的最佳提取工艺和成型工艺。方法将乙醇提取后的药渣与川芎、当归等药材合并,采用正交试验法,以阿魏酸的含量为指标,筛选最佳提取工艺;采用湿法制粒技术,通过单因素试验法,优选三七川归镇痛颗粒成型工艺。结果最佳提取工艺为药材加入12倍水,加热提取3次,每次1 h;颗粒剂的成型工艺为取处方量药材提取物,加入30%淀粉和5%蛋白糖混合均匀,用60%乙醇湿法制粒,干燥,即得。结论通过实验得出水煎工艺稳定、可靠,成型工艺简单、成本低,适合大工业生产。
Objective To optimize the extraction technology of water-soluble constituents from medicinal materials of Sanqi Chuangui granules and its forming process. Methods With the content of asafetida sour as markers, the extraction technology for the residue after ethanol extraction and R. Angelica sinensis, L. wallichii Franch. was optimized by orthogonal experimental design, we selected the forming process using wet granulating technology by single factor experiment. Results The optimize extracting procedure for the decoction of water is 12 times of water cooking 3 times（1 hour each time）, the best forming process was： 10% starch and 5%aspartame were added to prescription herbs extract, the granule was prepared by wet granulating technology with 60% ethanol and dry. Conclusion The optimize extracting was reliable, fundamental steady and the forming process was feasible, and it is comfortable for big factory production.
出处
《中国中医药现代远程教育》
2018年第4期90-93,共4页
Chinese Medicine Modern Distance Education of China
关键词
提取工艺
正交试验
阿魏酸
含量测定
成型工艺
extraction technology
orthogonal experimental design
asafetida sour
content determination
forming process
