延续性护理干预对宫颈癌化疗患者血清炎性因子及负性情绪的影响

The effect of continuity nursing intervention on serum inflammatory cytokines and negative emotions in cervical cancer patients with chemotherapy

目的研究延续性护理干预对宫颈癌化疗患者血清炎性因子及负性情绪的影响。方法选取我院妇产科2014年1月~2014年10月收治的宫颈癌化疗患者130例为研究对象,采用随机数字表法分为观察组和对照组,各65例,对照组实施常规化疗护理,观察组联合实施延续性护理干预,随访6个月后,比较两组血清炎性因子、症状自评量表(SCL-90)心理健康状况评分。结果观察组血清白细胞介素-6(IL-6)、白细胞介素-10(IL-10),肿瘤坏死因子-α(TNF-α)含量均明显低于对照组(P<0.05);躯体化、强迫症状、抑郁、焦虑、恐慌、精神病性等6项目评分均明显低于对照组(P<0.05)。结论延续性护理干预有助于改善宫颈癌化疗患者心理健康状况,可能与降低血清炎性因子含量等有关。

Objective To study the effect of continuity nursing intervention on serum inflammatory cytokines and negative emotions in cervical cancer patients with chemotherapy. Methods 130 cases cervical cancer patients with chemotherapy were divided into observation group and control group, the control group given standard chemotherapy nursing, observation group combined with continuity nursing intervention, followed up for 6 months, serum inflam- matory cytokines, SCL - 90 score were compared between two groups. Results The serum IL-6, IL-10, TNF-α of patients in observation group were significantly lower than those in control group （P 〈 0.05 ）; The scores of somatization, forcing symptoms, depression, anxiety, panic, psychoticism in patients in observation group were significantly lower than control group （P 〈 0.05 ） . Conclusion Continuity nursing intervention can improve mental health status in cervical cancer patients with chemotherapy, this effect maybe be related to decrease of the serum inflammatory cytokines.