有无基础疾病的肺隐球菌病患者临床及病理特点对比分析

Comparision of clinical and pathological characteristics between pulmonary cryptococcosis with or withoutunderlying disease

目的通过对比分析有无基础疾病的肺隐球菌病患者的临床及病理特点，提高肺隐球菌病的早期诊断准确率。方法收集2014年7月至2017年7月经郑州大学第一附属医院病理确诊的48例肺隐球菌病患者的临床资料，对比分析有基础疾病组与无基础疾病组的临床症状、影像学特点、病理类型的差异。结果与无基础疾病组相比，有基础疾病组年龄较高且病灶多为双肺多发（P〈0．05）；两组之间临床症状及病理类型比较，差异无统计学意义（P〉0．05）。结论肺隐球病临床表现无特异性，影像学表现多样，需及早行病原学检查、病理学检查，避免漏诊甚至误诊。

Objective To improve the accuracy of early diagnosis of pulmonary cryptococcosis by comparing the clinical and pathological characteristics of pulmonary cryptococcosis with or without underlying diseases. Methods Clinical datas of 48 patients with pulmonary cryptococcosis diagnosed by pathology of the First Affiliated Hospital of Zhengzhou University from July 2014 to July 2017 were collected. The clinical manifestations, imaging features and pathological characteristics of pulmonary cryptococcosis were analyzed. Results Compared to those without underlying disease, the patients with underlying disease had higher average age and mutiple lessions in both lungs （ P 〈0.05）. There was no significant difference in the clinical symptoms and pathological types between the two groups （ P 0.05） .Conclusions The clinical manifestations of pulmonary eryptococcosis are not specific, the imaging performances are diverse, the need for early pathogen examination and pathology to avoid missed or even misdiagnosed.