肺纤维化信号调控通路的研究进展

Research progress of signal transduction pathways of pulmonary fibrosis

肺纤维化作为一种慢性肺部疾病,患者被确诊的时间普遍在疾病的中后期,因此失去了最佳治疗时间,从而增加了患者的病死率。如果能在早期发现肺纤维化疾病的发病趋势,识别疾病特征,就能在最佳治疗时间采取相应的治疗方案,减少患者的痛苦,增加存活率。本文以目前对肺纤维化的研究作为出发点,探讨疾病的发展过程,再结合相关信号调节通路,为尽早确诊疾病和制定治疗方案提供可能性。

Pulmonary fibrosis, a chronic lung disease, is always diagnosed at middle or later stage of the disease, of which mortality is increased due to missing the best treatment period. However, if the tendency and characteristics of pulmonary fibrosis are identified at earlier stage, the corresponding therapeutic schedule would be adopted for patients at the best treatment period, which would decrease their suffering and increase their survival rate. On the basis of the previous studies on pulmonary fibrosis, this paper explores the developing process of the diseases and the corresponding signaling pathways, which provides the possibility for diagnosing the disease and formulating the effective therapeutic schedule as early as possible.