珠海市2010—2014年疑似预防接种异常反应监测数据分析

Analysis of abnormal reaction monitoring data of suspected vaccination in Zhuhai from 2010 to 2014

目的分析珠海市2010—2014年疑似预防接种异常反应(AEFI)发生的流行病学特征,评价疫苗的安全性。方法 AEFI个案数据来源于全国疑似预防接种异常反应信息管理系统,采用描述性流行病学方法分析各种疫苗AEFI发生率和其流行病学特征。结果珠海市2010—2014年报告AEFI平均发生率为12.15/10万剂次。报告AEFI主要为一般反应(占80.11%),报告发生率为9.73/10万剂次;异常反应报告发生率为2.02/10万剂次;偶合症报告发生率为0.35/10万剂次;心因性反应报告发生率为0.05/万剂次;无疫苗质量事故,无接种事故,无群体性反应。AEFI报告发生率居前5位的疫苗依次为23价肺炎疫苗(53.92/10万剂次),白破疫苗(53.60/10万剂次)、百白破IPV-Hib联合疫苗(41.30/10万剂次)、无细胞百白破疫苗(35.70/10万剂次)和7价肺炎疫苗(35.06/10万剂次)。结论珠海市AEFI主要为一般反应,报告发生率居前5位疫苗中以百白破系列疫苗为主。

Objective To analyze the occurrence features of adverse events following immunization（ AEFI） in Zhuhai City from 2010 to 2014,and to evaluate the implementation of AEFI surveillance system and the immunization safety related to vaccines. Methods AEFI data were collected through the national AEFI information system. We used descriptive epidemiological methods to analyze the incidence of various vaccine AEFI and its epidemiological characteristics. Results AEFI cases were reported in Zhuhai City from 2010 to 2014,and the estimated AEFI incidence rate was 12.15 per 100,000 doses. The AEFI report is general reaction（ 80.11%）,the report incidence rate was 9.73/10 million doses; abnormal reaction report incidence rate was 2.02/10 million doses; coupling disease report incidence rate was 0. 35/10 million doses; psychogenic reaction report incidence rate was 0. 05/million times; No vaccine quality accident,no inoculation accident,no group response. AEFI reporting rate ranked the top 5 of the order of 23 valent pneumococcal vaccine vaccine（ 53.92/10 million doses）,DPT vaccine（ 53. 60/10 million doses）,DPT IPV-Hib vaccine（ 41. 30/10 million doses）,DTa P vaccine（ 35.70/10 million doses） and 7 valent pneumonia vaccine（ 35.06/10 million doses）.Conclusions The AEFI of Zhuhai is mainly a general reaction. Reported incidence of the top 5 vaccines is DPT vaccine series.