Ⅰ期浸润性肺腺癌磨玻璃影及附壁样生长三维CT值定量分析

3D CT Value Analysis of Ground Glass Shadow and Coelentereous Growth in Stage Ⅰ Invasive Lung Adenocarcinoma

目的:探究采用三维CT值定量分析Ⅰ期浸润性肺腺癌磨玻璃影及其与病理上附壁样生长成分的相关性。方法:选取2013年6月至2017年6月收治的Ⅰ期浸润性肺腺癌患者168例,采用三维CT值定量分析软件及最大径线测量法计算Ⅰ期浸润性肺腺癌磨玻璃影成分比例,对浸润性腺癌的附壁样生长成分实施半定量评估,并对两者进行相关性分析。结果:采用三维CT值定量分析测量取得磨玻璃影成分比例为(0.21±0.18),根据最大径线法测量取得磨玻璃影成分比例为(0.44±0.36),病理切片半定量分析测量附壁成分比例为(0.29±0.24)。采用三维CT值定量及最大径线法分析测量所取得的磨玻璃影成分比例与附壁样生长成分比例均呈正相关(r=0.634和0.598,P=0.000)。最大径线法测得磨玻璃影成分比例与附壁样生长成分比例有3.8%在95%可信区间以外,三维CT值定量分析为4.4%,两者差异无统计学意义(P>0.05)。结论:通过三维值定量分析Ⅰ期浸润性肺腺癌患者磨玻璃影成分与附壁样生长成分具有显著相关性,其对辅助病理诊断具有重要临床意义,相比于最大径线法更能够全面反映Ⅰ期浸润性肺腺癌肿瘤的状况。

Objective： To investigate the relationship between ground glass opacity and the pathologic climax-like growth in patients with stage I invasive lung adenocarcinoma by three-dimensional CT. Methods： A total of 168 patients with stage inⅠ vasive pulmonary adenocarcinoma who were treated from June 2013 to June 2017 were selected. The components of ground glass in stage Ⅰinvasive lung adenocarcinoma were calculated by three-dimensional CT quantitative analysis software and the largest radial line measurement ratio, semi-quantitative assessment of the invasive growth of the adherent adenocarcinoma composition, and the correlation between the two. Results： The proportion of ground glass components was（0.21 ± 0.18）, the percentage of ground glass components was（0.44 ± 0.36）, the semi-quantitative analysis of pathological sections the ratio was（0.29 ± 0.24）. There was a positive correlation between the proportion of ground glass components and the proportion of climax-like growth components（r = 0.634 and 0.598, P = 0.000） by three-dimensional CT quantitative analysis and maximum diameter line analysis. The ratio of ground glass to the ratio of ground-glass components measured by the maximum diameter method was 3.8%. Outside the 95% confidence interval, the three-dimensional CT value was 4.4%. There was no significant difference between the two methods（P 0.05）. Conclusion： The three-dimensional quantitative analysis of stage I invasive lung adenocarcinoma patients with ground-glass components and climax-like growth component has a significant correlation, which has a significant clinical significance in the diagnosis of secondary pathology, and compared to the maximum diameter method is more comprehensive reflect the stage I invasive lung adenocarcinoma of the tumor status.