摘要
近年,有关长链非编码RNA(long non-coding RNA,LncRNA)的功能研究备受关注。研究表明,LncRNA与许多人类疾病的发生发展密切相关。进一步深入研究LncRNA的生物学功能,可能为阐明许多疾病的发病过程及机制带来重大的突破,并提供可能的干预靶点。心力衰竭是多种心血管疾病的终末阶段,最近的证据表明LncRNA与心血管疾病尤其与心衰有着密切的关系,本文就LncRNA在心力衰竭预后判断和治疗中的潜力研究进展做一综述。
Long non-coding RNA（ LncRNA） has attracted increasing attention over the recent years. It is closely related to the occurrence and development of human diseases based on numerous academic researches. Analysis of the biological function of LncRNA in depth may lead to great breakthroughs in clarifying pathogenesis of many diseases and provide possible targets for intervention. Recent studies have revealed the importance of LncRNA in the progression of heart failure（ HF）,the final stage of many cardiovascular diseases. This review summarized the new findings of LncRNA in prognosis and treatment of HF.
出处
《中国比较医学杂志》
CAS
北大核心
2018年第2期102-105,共4页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金(81670458,81470393,81370434)
上海中医药三年行动计划(ZY3-LCPT-2-1003)
浦东新区卫计委(PW2013E-1)
浦东新区科委(Pkj2013-z03)
关键词
LncRNA
心血管疾病
心衰
预后
治疗
LneRNA
cardiovascular disease
heart failure
prognosis
treatment
