血脂水平异常对缺血性脑卒中的影响

Effects of abnormal blood lipid levels on ischemic stroke

目的分析血脂水平异常对缺血性脑卒中的影响。方法将119例患者依据病情分组,对照组59例为同期住院无缺血性脑卒中的患者,观察组60例为缺血性脑卒中患者,检测两组患者的血脂水平,包括总胆固醇(TC)、高密度脂蛋白(HDL)、三酰甘油(TG)、低密度脂蛋白(LDL)、载脂蛋白-A1(Apo-A1)、载脂蛋白B(ApoB)以及脂蛋白(a)[Lp(a)],并进行对比分析。结果观察组HDL低于对照组,TC/HDL高于对照组,差异有统计学意义(P<0.05);观察组TC、TG、Apo-A1以及Lp(a)低于对照组,ApoB、LDL高于对照组,差异未见统计学意义(P>0.05)。结论高密度脂蛋白水平及总胆固醇/高密度脂蛋白比值均属于缺血性脑卒中患者的独立危险因素,临床上应根据患者的血脂水平,给予针对性预防及治疗,以降低缺血性脑卒中的发生率。

Objective To analyze the effect of abnormal blood lipid levels on ischemic stroke.Methods One hundred and nineteen patients were selected and divided into the control group（59 patients hospitalized without ischemic stroke） and the observation group（60 patients with ischemic stroke）.The blood lipid levels of the two groups were detected and compared,which including total cholesterol（TC）,high density lipoprotein（HDL）,triglycerides（TG）,low density lipoprotein（LDL）,apolipoprotein A1（Apo-A1）,apolipoprotein B（Apo B） and lipoprotein（a） [Lp（a）].Results Compared with the control group,HDL was lower and TC/HDL was higher in the observation group,and there was a statistically significant difference（P〈0.05）; TG,TC,Apo-A1 and Lp（a） in the observation group were lower than those in the control group,Apo B,LDL were higher than thoes in the control group,and the differences were not statistically significant（P〉0.05）.Conclusions The HDL levels and TC/HDL ratio are the independent risk factors of ischemic stroke.Clinically targeted prevention and treatment should be implemented according to the examination results of blood lipid levels of patients,so that the incidence of ischemic stroke could be redued.