异丙酚联合尼卡地平降低神经介入治疗性脑血管痉挛的临床效果

Clinical effect of propofol combined with nicardipine on ameliorating cerebral vasospasm induced by nerve interventional therapy

目的探讨异丙酚联合尼卡地平降低神经介入治疗性脑血管痉挛的临床效果。方法选取行神经介入治疗的98例患者作为研究对象,采用随机数字表法分为两组,每组49例。实验组采用异丙酚联合尼卡地平治疗,对照组采用异丙酚与硝酸甘油联合治疗,观察两组总有效率、神经痉挛时间及前脑中动脉收缩峰流速。结果实验组总有效率高于对照组,差异有统计学意义(P<0.05);实验组神经痉挛时间低于对照组,差异有统计学意义(P<0.05);实验组前脑中动脉收缩峰流速低于对照组,差异有统计学意义(P<0.05)。结论异丙酚联合尼卡地平降低神经介入治疗性脑血管痉挛的临床效果显著,值得临床推广应用。

Objective To investigate the clinical effect of propofol combined with nicardipine on ameliorating cerebral vasospasm induced by nerve interventional therapy.Methods Ninety-eight patients underwent intervention treatment were selected as the research objects,and they were divided into two groups（experiment group and control group）,according to the random table method,with 49 cases in each group.Patients in experiment group was given propofol combined with nicardipine treatment,and the patients in control group was given propofol and nitroglycerin combined treatment.The total efficiency,nerve spasm time and middle artery of two groups in the forebrain of systolic peak velocity were compared.Results The total effective rate in the research group was significantly higher than that of the control group,the difference was significant（P〈0.05）; the time of nerve spasm in the research group was lower than that in the control group,the difference was significant（P〈0.05）; the forebrain middle artery peak systolic velocity in the experiment group was lower than that of the control group,the difference was significant（P〈0.05）.Conclusions The clinical effect of propofol combined with nicardipine has significant effect on ameliorating the cerebral vasospasm caused by nerve interventional therapy,and it is worthy to be popularized.