B淋巴细胞在银屑病中的作用

The role of B lymphocyte in the pathogenesis of psoriasis

银屑病是一种常见的慢性炎症性皮肤免疫疾病,在多种诱发因素如外伤、感染、应激或药物等刺激下所致,角质形成细胞和多种天然免疫、获得性免疫细胞参与反应。既往研究认为经典的银屑病发病机制为固有免疫及T淋巴细胞介导的细胞免疫途径,近来越来越多的研究发现,B淋巴细胞在银屑病的发生发展中也起着重要作用。该文结合最近多项研究结果,综述B淋巴细胞对银屑病的发生发展的可能影响。

Psoriasis is a kind of chronic inflammatory immune skin disease, which contains multigenetic defects and caused by a variety of factors such as trauma, infection, stress or drug stimuli. Keratinocytes and a variety of natural immune, acquired immune cells involve in the pathogenesis of the disease. While dysregulation of innate immune system and adaptive immune system mediated by T lymphocytes has been recognized as a critical event in the disorder, more and more researches show that B lymphocytes may also play an important role in the pathogenesis of psoriasis, which will be discussed in this review.