中药热奄法治疗慢性稳定型心绞痛阴寒凝滞证50例回顾性队列研究

Chinese Medicine Hot Compress Therapy for Treatment of 50 Chronic Stable Angina Pectoris Patients with Pattern of Yin Cold Congelation and Stagnation: A Retrospective Cohort Study

目的评价中药热奄法治疗慢性稳定型心绞痛阴寒凝滞证患者的临床疗效。方法采用回顾性队列研究方法,通过医院电子病历系统收集2014年1月至2015年1月在江西中医药大学附属医院心血管病科慢性稳定型心绞痛住院患者,选择接受中药热奄法及常规西医治疗的50例患者为暴露组,匹配仅接受常规西医治疗的49例患者为非暴露组。比较两组治疗前后心绞痛发作及持续时间、心电图情况及中医证候积分,评价两组心绞痛疗效、心电图疗效及中医证候疗效。结果心绞痛疗效比较,暴露组优于非暴露组(P<0.05),暴露组心绞痛发作频次及持续时间均较非暴露组减少(P<0.01)。心电图疗效比较,暴露组总有效率为94.00%(45例/50例),非暴露组总有效率为71.43%(35例/49例),差异具有统计学意义(P<0.05)。中医证候疗效比较,暴露组总有效率98.00%(49例/50例),非暴露组总有效率81.63%(40例/49例),差异具有统计学意义(P<0.05)。两组治疗期间未出现严重不良反应。结论中药热奄法治疗慢性稳定型心绞痛临床疗效良好,可明显减缓心绞痛发作及持续时间、改善心电图情况及临床症状。

Objective To evaluate clinical efficacy of Chinese medicine hot compress therapy in the treatment of chronic stable angina pectoris with pattern of Yin cold congelation and stagnation. Methods A retrospective cohort study was conducted to collect hospitalized patients with chronic stable angina pectoris in the Department of Cardiology,Affiliated Hospital of Jiangxi University of Chinese Medicine from January 2014 to January 2015 through the hospital electronic medical record system. Fifty patients who accepted Chinese medicine hot compress therapy and conventional western medicine therapy were selected as the exposure group and 49 patients who only accepted conventional western medicine therapy were non-exposed group. The attack time and duration of angina pectoris,electrocardiogram outcome and Chinese medicine syndrome scores were compared between groups before and after treatment,and the curative effects in angina pectoris,electrocardiogram and Chinese medicine syndrome. Results The curative effect of angina pectoris was better in the exposure group than in the non-exposed group（P 〈0. 05） and the frequency and duration of angina pectoris in the exposure group were decreased than those in the non-exposed group（P 0. 01）.The total effective rate of electrocardiogram was 94. 00%（45/50） in the exposure group and 71. 43%（35/49） in the non-exposed group,the difference was statistically significant（P 〈0. 05）. The total effective rate of Chinese medicine syndrome was 98. 00%（49/50） in the exposure group and 81. 63%（40/49） in the non-exposed group,the difference was statistically significant（P 〈0. 05）. There was no serious adverse reaction during the treatment of the two groups. Conclusion Chinese medicine hot compress therapy seems to have good clinical efficacy in the treatment of chronic stable angina pectoris. It could significantly reduce the time of attack and duration of angina pectoris and improve the electrocardiogram and clinical symptoms.