多囊卵巢综合征中医“证”的组学研究进展

Research progress on the omics of traditional Chinese medicine syndrome of polycystic ovarian syndrome

多囊卵巢综合征(PCOS)是育龄期妇女常见的内分泌紊乱的疾病,文章回顾了PCOS中医"证"的代谢组学、脂质组学、多肽组学、糖组学等组学研究历程,分析比较了各种组学方法在PCOS"证"研究中的进展和差异,并结合本研究团队在PCOS痰湿证组学研究中的经验和体会,对PCOS中医"证"的组学研究进行了总结和探讨。提出了重视卵巢局部病理变化,合理运用多组学技术对PCOS"证"进行系统研究的设想。

Polycystic ovarian syndrome（PCOS） is a common endocrine disorder disease in women of child-bearing age. This paper reviewed the omics research progress of TCM syndrome of PCOS, such as metabonomics, lipidomics, peptidomics, glycomics, etc. The progress and differences between them were compared and analyzed. Combined with the research experience of our team, the omics research of TCM syndrome of PCOS were summarized and discussed. Paying attention to local pathological changes of ovarian and applying multi-group technology reasonably to make a systematic research on PCOS were put forward.