益气活血补肾降压方治疗高血压左室舒张功能障碍的临床研究

Clinical study on treatment of hypertensive left ventricular diastolic dysfunction by Yiqi Huoxue Bushen Jiangya Formula

目的:观察益气活血补肾方法防治高血压左室舒张功能障碍的临床疗效。方法:纳入122例高血压左室舒张功能障碍患者,随机分为3组,对照组予西医基础治疗加用中药颗粒模拟剂,补肾降压方组加用补肾降压方中药颗粒剂,益气活血补肾降压方组加用益气活血补肾降压方中药颗粒剂,疗程8周,观察益气活血补肾方法防治高血压左室舒张功能障碍的临床疗效。结果:治疗后左室舒张功能相关指标比较,益气活血补肾降压方组E/Ea比值组间及组内比较均有显著下降(P<0.05);益气活血补肾降压方组及补肾降压方组临床总有效率与对照组比较均显著提高(P<0.05)。结论:益气活血补肾降压方能降低高血压左室舒张功能障碍患者的E/Ea比值,可改善左室舒张期充盈,进而改善高血压左室舒张功能障碍,同时可显著改善气虚血瘀相关症状。

Objective： To observe the clinical effect of the method of benefiting qi for activating blood circulation and invigorating the kidney on the prevention and treatment of left ventricular diastolic dysfunction in patients with hypertension. Methods： A total of 122 patients with left ventricular diastolic dysfunction were randomly divided into three groups. The control group was treated with western medicine and traditional Chinese medicine granule mimetic. The original program group was treated with western medicine basic therapy and Bushen Jiangya Granules. The optimization program group was treated with the basic therapy and Yiqi Huoxue Bushen Jiangya Granules. The course of the treatment lasted for 8 weeks. The clinical effect of the method of benefiting qi for activating blood circulation and invigorating the kidney on the prevention and treatment of left ventricular diastolic dysfunction was observed. Results： The E/Ea ratio of the optimization program group was significantly lower than that of the control group（P〈0.05）. The total effective rate of the treatment group was significantly higher than that of the control group（P〈0.05）. Conclusion： Yiqi Huoxue Bushen Jiangya Formula can reduce the E/Ea ratio of left ventricular diastolic dysfunction in patients with hypertension, improve the left ventricular diastolic filling, the left ventricular diastolic dysfunction and the related symptoms of qi deficiency and blood stasis.