摘要
Nd doped nanoparticles is commonly used as bioimaging agents but presents poor stability. Here, a polymer coating is applied to NaYF4：Nd nanoparticles using a versatile step-by-step coating strategy. The as-synthesized NaYF_4：Nd@NaLuF_4@SiO_2@PS colloids show good stability in various polar solvent and are very stable in water at least for 6 months. These NaYF_4：Nd@NaLuF_4@SiO_2@PS colloids can exhibit strong down converting photoluminescence when excited by 808 nm lasers. Moreover, these NaYF_4：Nd@NaLuF_4@SiO_2@PS colloids accumulate in liver of mice when used as bio-imaging agents. which exhibit strong fluorescence luminescence in NIR Ⅱ window.
Nd doped nanoparticles is commonly used as bioimaging agents but presents poor stability. Here, a polymer coating is applied to NaYF4：Nd nanoparticles using a versatile step-by-step coating strategy. The as-synthesized NaYF_4：Nd@NaLuF_4@SiO_2@PS colloids show good stability in various polar solvent and are very stable in water at least for 6 months. These NaYF_4：Nd@NaLuF_4@SiO_2@PS colloids can exhibit strong down converting photoluminescence when excited by 808 nm lasers. Moreover, these NaYF_4：Nd@NaLuF_4@SiO_2@PS colloids accumulate in liver of mice when used as bio-imaging agents. which exhibit strong fluorescence luminescence in NIR Ⅱ window.
基金
Project supported by the State Key Basic Research Program of China(2015CB931800)
the National Natural Science Foundation of China(21231004,21375024)
