糖尿病足神经病变动物模型研究进展

Advances in research of animal models of diabetic foot neuropathy

糖尿病足属于糖尿病周围神经病变(diabetic peripheral neuropathy,DPN),是以周围神经功能障碍为其特点。探讨该疾病的有效动物模型,可以更深入了解其发生和发展规律、发病机制、预防及治疗措施。因此,在研究疾病的诊断、预防和治疗过程中,合理构建动物模型至关重要。迄今为止,大鼠、小鼠、裸鼠、转基因鼠等均被尝试作为糖尿病足神经病变模型研究的实验动物。通过不同的方式,如缺血再灌注、切除或结扎神经、烫伤等造成神经损伤来建模。本文就糖尿病足神经病变动物模型的研究进展作一综述。

Diabetic foot with diabetic peripheral neuropathy（ DPN） can lead to peripheral nerve dysfunction. Exploring appropriate animal models of the disease can make a better understanding of the occurrence,development,pathogenesis,prevention and treatment of DPN. Therefore,a reasonable construction of animal models is related to the success of experimental research. Up to date,experimental animals used in the research of diabetic foot neuropathy include rats,nude mice,transgenic mice,and so on. Nerve injury models can be generated by different means,such as ischemia reperfusion,resection or ligation of nerves and scalds. This article will review the recent research progress of diabetic foot neuropathy animal models.