强直性脊柱炎患者血清胶原的表达及临床意义

Expression of serum collagen in patients with ankylosing spondylitis and its clinical significance

目的观察胶原在强直性脊柱炎患者血清中的表达。方法 30例早中期AS患者入组作为AS组,并以30例健康志愿者为对照组。分别检测AS组和对照组受试者外周血清胶原水平。AS组患者评估Bath强直性脊柱炎病情活动指数(BASDAI)、Bath强直性脊柱炎功能指数(BASFI)、Bath强直性脊柱炎测量指数(BASMI)及检测血沉、C反应蛋白。结果 AS组胶原水平较健康对照组显著升高(P<0.05)。AS组患者按CT结果分级,Ⅱ、Ⅲ级AS患者外周血清胶原水平均显著高于对照组(P<0.05);Ⅰ级AS患者外周血清胶原水平与对照组比较无显著差异(P>0.05)。HLA-B27阳性患者血清胶原水平与HLA-B27阴性患者血清胶原水平比较无显著性差异(P>0.05)。Pearson线性相关分析显示胶原水平和BASDAI,BASFI,BASMI,ESR及CRP呈显著正相关(P<0.05)。结论胶原在AS患者外周血清呈高表达,与AS病情有着密切的关联,可以作为AS病情监测的一个重要指标。

Objective To observe the expression of collagen in serum of patients with ankylosing spondylitis. Methods 30 patients with early and middle stage AS were enrolled in AS group, and 30 healthy volunteers were used as control group. The levels of peripheral serum collagen in AS group and control group were detected. The Bath Ankylosing Spondylitis Disease Activity Index（BASDAI）, Bath Ankylosing Spondylitis Function Index（BASFI）, Bath Ankylosing Spondylitis Measurement Index（BASMI） of patients in the AS group were evaluated. The ESR and C-reactive protein were detected. Results The level of collagen in the AS group was significantly higher than that in the healthy control group （P〈O.05）. Patients in the AS group were graded according to the CT results. The levels of peripheral blood collagen in patients with grade 1I and HI AS were significantly higher than those in the control group（P〈0.05）. There was no sig- nificant difference in the level of serum collagen in grade I AS group and control group（P〉0.05）. There was no signif- icant difference in serum collagen level between HLA-B27 positive patients and HLA-B27 negative patients（P〉0.05）. Pearson linear correlation analysis showed a significant positive correlation between collagen level and BASDAI, BAS- FI, BASMI, ESR and CRP（P〈O.05）. Conclusion Collagen is highly expressed in peripheral blood of AS patients, and is closely related to AS condition, which can be used as an important index for monitoring AS condition.