慢性阻塞性肺疾病及哮喘重叠综合征患者临床特征及其区别分析

Analysis of clinical features and difference in patients with chronic ob-structive pulmonary disease and asthma COPD overlap syndrome

目的探讨慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)以及哮喘重叠综合征(asthma COPD overlap syndrome,ACOS)患者临床特征及其区别。方法前瞻性选取2016年2月~2017年2月我院收治的COPD患者60例以及ACOS患者60例,统计对比两组患者临床特征、肺功能及实验室指标方面的区别。结果两组患者的性别无明显差异(P>0.05),ACOS患者的年龄、BMI指数以及外周血嗜酸性粒细胞百分比高于COPD患者(P<0.05);ACOS患者的FEV_1、FCV以及FEV_1/FCV低于COPD患者,同时Dlco-SB、Fe NO高于COPD患者(P<0.05);实验室检查结果对比方面,ACOS患者PaO_2低于对照组,同时WBC、CRP等指标高于对照组(P<0.05)。结论ACOS患者的典型特征为气流受限,同COPD患者较为类似,因此需要分辨二者临床特征以及实验室指标等方面的区别,从而准确鉴别并为患者提供针对性治疗。

Objective To investigate the clinical features and differences of patients with chronic obstructive ~ulmonary disease（COPD） and asthma COP/） overlap syndrome （ACOS）. Methods 60 patients with COPD and 60 patients with A- COS who were treated in our hospital from February 2016 to February 2017 were prospectively selected. The clinical characteristics, pulmonary function and laboratory indicators of the two groups were compared statistically. Results There was no significant gender difference between the two groups（P〉0.05）. The age, BMI and the percentage of periph- eral blood eosinophils in ACOS patients were higher than COPD patients （P〈O.05）. The FEV~, FCV and FEV,/FCV in ACOS patients were lower than those in COPD patients, while Dlco-SB and FeNO were higher than COPD （P〈O.05）. In terms of laboratory examination results, PaO2 in ACOS patients was lower than that in control group and WBC and CRP were significantly higher than control group （P〈0.05）. Conclusion The typical characteristics of patients with ACOS are limited airflow and are similar to patients with COPD. Therefore, it is necessary to distinguish the difference between the clinical features and laboratory indicators of the two types of patients, so as to identify accurately and provide tar- geted treatment to patients.