盐酸氨溴索注射液治疗慢性支气管炎急性发作的效果观察

Clinical observation of Ambroxol Hydrochloride injection in the treatment of acute attack stage of chronic bronchitis

目的探讨急性发作期慢性支气管炎患者在使用盐酸氨溴索注射液治疗后的效果。方法选取研究对象为2015年5月至2016年5月收入的68例急性发作期慢性支气管炎患者,随机分为观察组与对照组,34例患者采用盐酸氨溴索注射液治疗作为观察组,另外34例患者采用常规治疗作为对照组。比较两组患者实施不同治疗对治疗效果、不良反应、咳嗽咳痰消失、住院、喘息消失时间及动脉血二氧化碳分压、动脉血氧分压的影响。结果在治疗总有效率上,观察组(97.1%)显著比对照组(85.3%)高(χ2=8.609,P<0.05);观察组在咳嗽咳痰消失、住院、喘息消失时间上明显比对照组短(t=24.784、15.960、14.992,P<0.05);治疗后在动脉血二氧化碳分压上观察组显著比对照组低(t=7.195,P<0.05),在动脉血氧分压上显著比对照组高(t=3.665,P<0.05);且不良反应发生率上观察组(2.9%)比对照组(11.8%)高(χ2=5.712,P<0.05)。结论采用盐酸氨溴索注射液对急性发作期慢性支气管炎患者展开治疗,不仅能降低不良反应发生率,提升治疗效果,还能缩短咳嗽咳痰消失、住院、喘息消失时间,降低动脉血二氧化碳分压,提升动脉血氧分压。

Objective To observe the clinical effect of Ambroxol Hydrochloride injection in the treatment of acute attack stage of chronic bronchitis.Methods 68 patients with acute attack stage of chronic bronchitis treated from May 2015 to May 2016 in our hospital were selected.The subjects were randomly divided into two groups,34 cases each group;the observation group took the Ambroxol Hydrochloride injection;the control group took the conventional therapy.After treatment,the clinical effect,adverse reactions,disappearance time of cough and expectoration, hospitalization time and disappearance time of wheezing as well as the index of PaCO_2（partial arterial pressure of carbon dioxide） and PaO_2（partial arterial pressure of oxygen） for two groups were compared.Results The total effective rate for observation group（97.1%） was significantly higher than that of control group（85.3%）（χ2=8.609,P〈0.05）;the disappearance time of cough and expectoration,hospitalization time and disappearance time of wheezing for observation group were significantly shorter than those of control group（t=24.784,15.960,14.992,P〈0.05）;after treatment,the index of PaCO_2 for observation group was significantly lower than that of control group（t=-7.195,P〈0.05）;after treatment,the index of Pa O for observation group was significantly higher than that of control group（t=3.665,P〈0.05）;the adverse event rate for observation group（2.9%） was significantly lower than that of control group（11.8%）（χ2=5.712,P〈0.05）.Conclusion The Ambroxol Hydrochloride Injection on the treatment of acute exacerbation of chronic bronchitis patients,not only can reduce the incidence of adverse reactions,improve the therapeutic effect,shorten the hospitalization,cough disappeared,wheezing disappearance time and reducing PaCO_2, increase arterial oxygen pressure.