海洋来源Neolamellarin A类似物的神经保护活性

Neuroprotective Activity of Neolamellarin A Analogues

目的生物碱是自然界中普遍存在的一类含氮的碱性有机化合物,其中海洋生物碱因具有广泛的生物活性而受到极大关注。Neolamellarin A是1种来源于海洋动物海绵并具有新颖吡咯类骨架的生物碱。目前对Neolamellarin A类生物碱的研究探索刚刚起步,希望可以通过更多的活性研究对其加以全面的开发。方法采用细胞毒活性检测(MTT法)及神经细胞保护模型对五个新颖Neolamellarin A的3,4二芳基取代全甲基化类似物进行检测。结果发现该类3,4二芳基取代全甲基化的Neolamellarin A类似物较弱的细胞毒活性和突出的神经保护活性。结论实验结果扩展了该类Neolamellarin A类似物潜在的应用方向并丰富了海洋生物碱的生物功能。

Objective Alkaloids are a class of nitrogenous compounds found in nature.Marine alkaloids deserve great attention with widespread biological activities.Neolamellarin A is a kind of marine alkaloids,possessing bisaryl-pyrrole structural features.There is limited understanding of the biological activity of Neolamellarin class A alkaloids and the exploration of novel biological activity of these compounds is imperative.Methods The 3,4-bisaryl-N-alkylated permethylated analogues of Neolamellarin A were tested by cytotoxic activity assay（MTT）and PC12 neuron-like cell model.Results It was found that the 3,4-bisaryl-N-alkylated permethylated analogues of Neolamellarin A had weaker cytotoxic activity and prominent neuroprotective activity.Conclusion The neuroprotective activities extend the potential application of Neolamellarin A analogues and enrich the biological functions of the marine alkaloids.