血浆硬化蛋白浓度与膝关节骨关节炎软骨退变程度的相关性

Relationship between plasma sclerostin and radiographic severity of knee osteoarthritis

目的分析血浆硬化蛋白(sclerostin)水平与膝骨关节炎(KOA)严重程度的相关性。方法选取KOA女性患者和健康女性各95例,ELISA检测血浆中sclerostin、CTX-II和aggrecan降解片段AGG1及AGG2的浓度。根据Kellgrene&Lawrence(KL)分级对95例KOA患者进行X线分级,并进行相关分析。结果 KOA患者血浆sclerostin浓度明显低于对照组(P<0.001)。血浆sclerostin浓度与KL分级负相关(r=-0.828,P<0.001),与血浆CTX-II(r=-0.917,P<0.001)、AGG1(r=-0.658,P<0.001)、AGG2(r=-0.583,P<0.001)负相关。结论 KOA患者的血浆sclerostin浓度与软骨退变程度相关,有助于在临床上监测病情进展以及评价病情的严重性。

Objective To investigated the relationship between plasma sclerostin （SOST） and knee osteoarthritis （KOA）. Methods A total of 95 patients with KOA and 95 healthy people were involved. Plasma sclerostin, CTX-II, AGG1 and AGG2 levels were measured by ELISA. The 95 patients were divided based on Kellgren-Law- fence classification. The correlation between plasma SOST level and KL classification, CTX-II, AGGI and AGG2 were analyzed. Results Plasma SOST level in KOA was significantly lower than that in control gronp （P 〈 0.001 ）. SOST level was negatively correlated with KL grade （r = -0.828, P 〈 0.001）, also with CTX-II （r = -0.917, P 〈 0.001）, AGG1 （r = -0.658, P 〈 0.001） and AGG2 （r = -0.583, P 〈 0.001）. Conclusions SOST level in KOA patients is related to the degree of cartilage degeneration. Thus, it helps to monitor the progress and evaluate the severity of the KOA.