促性腺平抑因子在女性生殖方面的研究进展

Progress of Gonadotrophin surge-attenuating factor in female reproduction

促性腺平抑因子(GnSAF)是由卵泡刺激激素(FSH)刺激卵巢产生的一种可以降低垂体对促性腺激素释放激素(GnRH)反应的蛋白分子,其主要作用是抵抗雌激素,从而负反馈调节黄体生成激素(LH)合成与分泌,参与卵泡募集、生长发育、排卵,并与卵巢反应性、子宫内膜容受性及控制性超促排卵(COH)结局等女性生殖活动密切相关。

Gonadotrophin surge-attenuating factor（GnSAF）,a protein molecule,which is produced by ovaries under the stimulation of follicle stimulating hormone,can reduce the reaction of pituitary gland to gonadotropin-releasing hormone（GnRH）. Its primary role is to resist to estrogen,and regulate the synthesis and secrection of luteinizing hormone（LH）by negative feedback regulation mechanism. And then,participate in follicular recruitment,growth and development as well as ovulation. Furthermore,GnSAF is closely related with female reproductive activities such as ovarian reaction,endetrial receptivity,controlled ovarian hyperstimulation（COH）outcomes and so on.