右美托咪定对椎管内麻醉手术患者应激反应的影响

Effects of Dexmedetomidine on Stress Response in Patients Undergoing Spinal Anesthesia Surgery

目的:探讨右美托咪定对椎管内麻醉手术患者应激反应的影响。方法:选取2015年8月—2016年7月宜都市第一人民医院收治的手术患者82例作为研究对象,以随机数字表法分为观察组和对照组,每组41例。所有患者均行椎管内麻醉,对照组患者给予丙泊酚,观察组患者给予右美托咪定。观察两组患者给药前后听觉诱发电位指数(auditory evoked potential index,AAI)变化和不良反应发生情况。结果:给药前,两组患者AAI的差异无统计学意义(P>0.05);给药30、60 min后及术后,观察组患者AAI明显低于对照组,差异均有统计学意义(P<0.05);观察组患者的不良反应发生率为9.8%(4/41),明显低于对照组的24.4%(10/41),差异有统计学意义(P<0.05)。结论:椎管内麻醉术中应用右美托咪定能有效控制患者的应激反应,稳定AAI,且不良反应少。

OBJECTIVE： To probe into the effects of dexmedetomidine on stress response in patients undergoing spinal anesthesia surgery. METHODS： 82 patients undergoing spinal anesthesia surgery admitted into Yidu the First People＇s Hospital from Aug. 2015 to Jul. 2016 were extracted to be divided into observation group and control group via the random number table,with 41 cases in each. All patients received intraspinal anesthesia,and the control group was given propofol,the observation group was treated with dexmedetomidine. Changes of auditory evoked potential index（ AAI） before and after administration and incidence of adverse drug reactions of two groups was observed.RESULTS： Before administration,there was no statistical significance between two groups in AAI（ P〈0. 05）; after administration of 30,60 min and after surgery,the AAI of observation group was significantly lower than that of control group,with statistically significant difference（ P〈0. 05）. The incidence of adverse drug reactions of observation group was 9. 8%（ 4/41）,significantly lower than that of control group 24. 4%（ 10/41）,with statistically significant difference（ P〈0. 05）. CONCLUSIONS： The application of dexmedetomidine can effectively control the stress response in patients undergoing spinal anesthesia surgery,stabilize the AAI with fewer adverse drug reactions.