利奈唑胺治疗骨科术后感染的疗效及对血清炎性因子水平的影响

Efficacy of Linezolid in Treatment of Postoperative Infection Among Patients in Orthopedics Department and its Effects on Serum Inflammatory Factors

目的:探讨利奈唑胺治疗骨科术后感染的疗效及对血清炎性因子水平的影响。方法:选取2014年6月—2016年6月河南大学附属郑州市骨科医院收治的骨科术后感染患者86例作为研究对象,以随机数字表法分为观察组和对照组,每组43例。对照组患者给予头孢唑林钠治疗,观察组患者给予利奈唑胺治疗。对比观察两组患者的临床疗效,治疗前后肿瘤坏死因子(TNF-α)、白细胞介素6(IL-6)和白细胞介素8(IL-8)水平及不良反应发生情况。结果:观察组患者的总有效率为97.7%(42/43),明显高于对照组的83.7%(36/43),差异有统计学意义(P<0.05);治疗后,观察组患者的TNF-α、IL-6和IL-8水平明显低于对照组,差异均有统计学意义(P<0.05);观察组、对照组患者不良反应发生率分别为11.6%(5/43)、14.0%(6/43),差异无统计学意义(P>0.05)。结论:利奈唑胺治疗骨科术后感染的疗效显著,可有效改善患者临床症状,降低血清炎性因子水平,不良反应少,安全性高。

OBJECTIVE： To probe into the efficacy of linezolid in treatment of postoperative infection among patients in orthopedics department and its effects on serum inflammatory factors. METHODS： 86 patients with postoperative infection admitted into Zhengzhou Orthopaedics Hospital Affiliated to Henan University from Jun. 2014 to Jun. 2016 were selected and divided into observation group and control group via random number table,with 43 cases in each. The control group was treated with cefazolin sodium,while the observation group was given linezolid.Differences in clinical efficacy,levels of tumor necrosis factor-α（ TNF-α）,interleukin-6（ IL-6）,interleukin-8（ IL-8）,incidences of adverse drug reactions between two groups were observed and compared. RESULTS： The total effective rate of observation group（ 97. 7%,42/43） was significantly higher than that of the control group（ 83. 7%,36/43）,with statistically significantly difference（ P〈0. 05）; after treatment,the TNF-α,IL-6 and IL-8 levels of observation group were significantly lower than those of the control group,with statistically significantly differences（ P〈0. 05）; the incidences of adverse drug reactions of observation group and control group were respectively 11. 6%（ 5/43） and 14. 0%（ 6/43）,the difference had no statistical significance（ P〈0. 05）. CONCLUSIONS： The efficacy of linezolid in treatment of postoperative infection among patients in orthopedics department is remarkable,which can significantly improve patients＇ clinical symptoms,reduce serum inflammatory factors levels,with low incidence of adverse drug reactions and high safety.