90例药品不良反应报告

Reports on 90 Cases of Adverse Drug Reaction

目的:探讨上海市松江区妇幼保健院(以下简称"我院")药品不良反应(adverse drug reaction,ADR)发生的特点和规律,为临床合理用药提供参考。方法:收集我院2016年1月—2017年6月成功上报至国家ADR监测系统的ADR报告90例,采用Excel软件对引发ADR的给药途径、引发ADR的药物种类及具体药品、累及器官和(或)系统及临床表现等进行回顾性统计分析。结果:90例ADR报告中,静脉滴注致ADR病例数最多(49例,占54.44%);ADR涉及9类药物32个品种,以妇产科用药最为多见,例次数排序居前3位的药品分别为硫酸镁注射液、注射用头孢呋辛钠和左炔诺孕酮宫内节育系统;ADR主要累及消化系统,其次为皮肤及其附件。结论:ADR的发生与多种因素有关,临床应加强ADR的监测,增强上报意识,促进合理用药。

OBJECTIVE： To probe into the characteristics and regularities of adverse drug reaction（ ADR） in the Maternal and Child Health Hospital of Songjiang（ hereinafter referred to as ＂our hospital＂）,so as to provide reference for clinical rational drug application. METHODS： 90 cases of ADR reported to national ADR monitoring system from Jan. 2016 to Jun. 2017 were collected,Excel was adopted to conduct retrospective analysis on ADR reports in terms of ADR-inducing administration routes,categories of ADR-inducing drugs and specific medicine,ADR involved organs and（ or） systems,clinical manifestations,etc. RESULTS： Of the 90 cases of ADR reports,intravenous drip had induced the most ADR; 32 kinds of 9 categories of drugs were involved,mostly was medication in department of gynaecology and obstetrics,the top 3 drugs ranked in the number of ADR cases were respectively magnesium sulfate injection cefuroxime sodium for injection and mirena; ADR mainly involved digestive system,the secondly was skin and its accessories. CONCLUSIONS： The occurrence of ADR was related to various factors,ADR monitoring and reporting should be reinforced to promote rational medication.