摘要
DNA methylation plays an essential role in mammalian development[1].However,how DNA methylation is inherited between generations and if there is family-specific DNA methylation pattern remains to be elucidated[2].In this study,we collect male blood samples including a big pedigree of the descendants of an ancient Chinese empire and samples from different haplogroups to study their whole genome DNA methylation pattern.We find 115 male family-specific methylation sites from three families.The difference of whole genome DNA methylation pattern correlates
DNA methylation plays an essential role in mammalian development [1 ]. However, how DNA methylation is inherited between generations and if there is family-specific DNA methylation pattern remains to be elucidated [2]. In this study, we collect male blood samples including a big pedigree of the descendants of an ancient Chinese empire and samples from different haplogroups to study their whole genome DNA methylation pattern. We find 115 male family-specific methylation sites from three families. The difference of whole genome DNA methylation pattern correlates with the remote divergence time between samples. Overall, we showed a high correlation between the DNA methylation profile and the blood relationship within male family members, but not female family members.
基金
supported by Precision Medicine Research Program of the Chinese Academy of Sciences(KJZD-EWL14)
Strategic Priority Research Program of the Chinese Academy of Sciences(XDA01040407)
National Natural Science Foundation of China(31471395,91019024,31540033 and 31100558)
National Basic Research Program of China(2012CB518302 and2013CB911001)
One Hundred Person Project of the Chinese Academy of Sciences
