摘要
广谱抗癫痫药物丙戊酸盐是全球范围内应用最为广泛的抗癫痫药物。药物基因组学研究发现,基因可以影响丙戊酸盐的药物代谢动力学参数。本文综述针对丙戊酸盐的药物基因组学主要研究内容和研究方向。
Valproate is widely used in the treatment of epilepsy. Recently, the pharmacogenetics studies have showed that some genes could affect the pharmacokinetics of valproate. This review describes the pharmacogenomics of valproate and its research directions.
出处
《世界临床药物》
CAS
2018年第2期135-141,共7页
World Clinical Drug
