桥本氏病患者血清促甲状腺激素水平升高对甲状腺组织癌变的影响

Effects of Elevated Serum Thyrotropin Levels on Thyroid Tissue Cancer in Patients with Hashimoto's Disease

目的分析桥本氏病患者血清促甲状腺激素水平升高对甲状腺组织癌变的影响。方法选取167例桥本氏病患者为研究对象,根据患者是否合并甲状腺乳头状癌(papillary thyroid carcinoma,PTC),将其分为无PTC组和合并PTC组,分别为94例和73例。检验两组患者的血清促甲状腺激素水平,并探讨其与甲状腺组织癌变的相关性。结果合并PTC组的血清TSH水平(3.34±1.36)mIU/L,明显高于无PTC组[(2.19±1.17)mIU/L](P<0.05),而其血清TGAb及血清TPOAb水平明显低于无PTC组(P<0.05);合并PTC组患者中血清TSH水平升高者比例(32.88%)明显高于无PTC组(23.40%)(P<0.05);年龄、性别及血清TSH水平可能是影响桥本氏病患者诱发甲状腺组织癌变的危险因素(P<0.05)。结论桥本氏病患者血清促甲状腺激素水平的升高可能会促进甲状腺组织的癌变。

Objective To investigate the effect of elevated serum thyrotropin level on thyroid tissue cancer in patients with Hashimoto＇s disease. Methods A total of 167 patients with Hashimoto＇s disease were enrolled in this study . According to whether patients had papillary thyroid carcinoma （PTC）, they were divided into without PTC group and combined with PTC group ,94 cases and 73 cases ,respectively. Serum thyrotropin levels were measured in both groups and the association with thyroid tissue was examined. Results Serum TSH level in combined PTC group （ 3.34 ±1.36） mIU/L was significantly higher than that of without PTC group [ （ 2.19 ±1.17 ） mlU/L ] （ P 〈 0.05 ）, while serum TGAb and serum TPOAb levels were significantly lower than those without PTC （P 〈 0.05 ）. The proportion of TSH in patients with PTC was 32.88% higher than that of patients without PTC （ 23.40% ） （ P 〈 0.05 ）. Age, gender and serum TSH levels were likely to be the risk factors of Hashimoto＇s disease induced thyroid cancer （P 〈 0.05 ）. Conclusion Elevated levels of serum thyrotropin in patients with Hashimoto＇s disease may promote the carcinogenesis of thyroid tissue.