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基于关联规则和复杂系统熵聚类的骨折术后便秘用药规律研究 被引量:4

Analysis on Medication Rule in Herbal Prescriptions for Constipation after Fracture Operation based on Association Rules and Complex System Entropy Cluster
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摘要 目的:分析治疗骨科术后便秘的中药内服处方的用药规律。方法:通过中国知网CNKI、重庆维普VIP、万方、中国生物医学文献数据库搜集2011年至2016年9月7日治疗骨科术后便秘的中药内服处方,采用TCMISS中医传承辅助平台软件提取分析处方中各药物的使用频次、四气五味归经、归类以及药物之间的关联规则等。结果:对117个中药处方进行分析,使用频率较高的中药有大黄、厚朴、当归、甘草、桃仁、枳实、芒硝等。药物的四气分布主要为温、平、寒。药物的五味分布主要为苦、辛、甘。药物的归经分布主要为脾、胃、肝、大肠。药物归类分布主要为菊科、茄科、伞形科。大黄、厚朴、当归、桃仁、枳实、芒硝、甘草等均为临床治疗骨折术后便秘最常用的中药。结论:中药治疗骨折术后便秘以峻下热结、补血活血为主要治法,常用处方为当归承气汤合桃仁承气汤,关键药物组合是大黄与厚朴,处方用药应以"峻下热结不伤血,补血活血不致瘀"为则。 Objective: To analyze the medication rule in herbal prescriptions for postoperative constipation in patients who received surgical treatment of fractures. Methods: Herbal prescriptions for postoperative constipation in patients who received surgical treatment of fractures were searched from Chinese National Knowledge Infras- tructure, VIP database, Wanfang database and Chinese Biomedical Database, from 2011 to 2016. Chinese medicine inheritance support system (TCMISS) has been used to analyze the frequency, four qi, five flavors, meridian entry, plant classification of drugs, and the association rules between drugs. Results: Based on the analysis of 117 herbal prescriptions, herbs used with high frequency were Dahuang (Rheum Officinale), Houpu (Magnoliae Officinalis Cortex), Dang'gui (Angelica Sinensis), Gancao (Glycyrrhizae Radix), Taoren (Persicae Se- men), Zhishi (Aurantii Fructus Immaturus), Mangxiao (Mirabilite), et.al. Four qi of drugs were mainly consisted of warmth, neutral and coldness. Five flavors of drugs were mainly consist of bitter, pungent and sweet. Meridi- an entrys were mainly consisted of spleen, stomach, liver, large intestine. Plant classification of drugs were mainly consisted of Asteraceae, Solanaceae, Apiaceae. Dahuang (Rheum Officinale), Houpu (Magnoliae Officinalis Cortex), Dang'gui (Angelica Sinensis), Gancao (Glycyrrhizae Radix), Taoren (Persicae Semen), Zhishi (Aurantii Fructus Immaturus), Mangxiao (Mirabilite), et.al, which were the most commonly used traditional Chinese Medicine for postoperative constipation in patients who received surgical treatment of fractures. Conclusion: Themain principles of treatment for postoperative constipation in patients who received surgical treatment of fractures is using drastic purgative method while enriching blood and promoting blood flow. The most commonly used traditional Chinese medicine prescription was Danggui Chengqi Decoction (当归承气汤) and Peach Kernel Qi-Coor- dinating Decoction (桃仁承气汤). The key drug combination are Rheum Officinale and Magnoliae Offieinalis Cortex. The medication principle of the medicine should use drastic purgative method and prevent the loss of blood while enrich blood and promote blood flow but not lead to blood stasis.
出处 《中医药导报》 2018年第4期49-51,55,共4页 Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金 广东省科技计划项目(2012B061700037) 广东省财政厅专项([2014]157号) 广东省中医药局建设中医药强省重点科研项目(20123006) 广东省中医院中医药科学技术研究专项(YK2013B2N19)
关键词 骨折 术后便秘 峻下秘结 补血活血 组方规律 关联规则 聚类算法 Fracture Postoperative Constipation Drastic Purgation Enriching Blood And Promoting Blood Flow Composition Principle Of Prescription Association Rules Clustering Algorithm
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