化合物[Cd·L·DMF·O2]n的合成、结构及其与DNA作用研究

Synthesis, Structure and DNA Binding of Complex[Cd·L·DMF·O_2]_n

选用2-氨基对苯二甲酸为配体与Cd Cl2反应,通过水热法合成了化合物[Cd·L·DMF·O2]n,利用元素分析和单晶X射线衍射对配合物结构进行了表征。通过荧光光谱法测定了化合物与鱼精DNA的结合作用。通过凝胶电泳技术分析了化合物切割p BR322质粒DNA的能力。这给了我们关于抗癌抗病毒药研究的建设性意见。

A new complex [Cd·L·DMF·O_2]_n was synthesized from 2-amino terephthalic acid and under CdCl_2 by hydrothermal method, and then the complex structure was characterized by the elemental analysis and single crystal X-ray diffraction. The binding of the complex to the fish sperm DNA was measured by fluorescence spectroscopy. The ability of the complex for cleaving pBR322 plasmid DNA was analyzed by gel electrophoresis.