中国人脂联素基因rs2241766单核苷酸多态性与高血压相关性研究的Meta分析

Associations on the ADIP0Q gene rs2241766 polymorphism and hypertension in Chinese population: a systematic review and meta-analysis

目的:探讨中国人脂联素基因(ADIP0Q)rs2241766单核苷酸多态性与高血压的相关性。方法:通过文献检索收集2016年4月以前完成或公开发表的,脂联素基因rs2241766单核苷酸多态性与高血压相关性的病例对照研究,剔除不符合要求的文献,以漏斗图检验入选文献的偏倚性,并根据各入选文献结果的同质性检验结果进行数据合并,计算总比值比,Meta分析采用Review Manager 5.3版软件。结果:总共有8篇文献纳入本次研究,其中有1 907例高血压患者和2 263例正常对照组。Meta分析结果显示:脂联素基因rs2241766等位基因模型(G VS T)合并后的总[OR=1.13,95%CI:1.03,1.24];共显性模型(GG VS TT)合并后的总[OR=1.33,95%CI:1.08,1.65]。结论:中国人脂联素基因rs2241766单核苷酸多态性可增加患高血压的风险。

Objective： To explore the associations between single nucleotide polymorphisms of AD- IPOQ gene and hypertension in Chinese population. Methods： We surveyed case-control studies on the associations of ADIPOQ gene polymorphisms with hypertension in Chinese Biomedical Literature Database, Wanfang and China National Knowledge Infrastructure. All articles were rigorously evaluated and screened according to inclusion criteria; meta-analysis was performed for the included studies using Review Manager 5.3 software. Results： Eight case-control studies of a total of 1907 hypertension patients and 2 263 control subjects met the inclusion criteria. The pooled result from ADIPOQ gene rs2241766 showed increased risk in allelic model （OR = 1.13, 95% CI = 1.03 - 1.24） and homozygote model （ OR = 1.33, 95% CI = 1.08 - 1.65 ）. Conclusion： The ADIPOQ rs2241766 polymorphism is found to be associated with a significant increase in hypertension risk based on our analysis.