期刊文献+

丙型肝炎病毒抑制剂达拉他韦中国专利申请情况解析

Analysis of patent applications of the HCV inhibitor daclatasvir in China
原文传递
导出
摘要 达拉他韦是百时美施贵宝公司研发的一种丙型肝炎病毒NS5A蛋白抑制剂。本文通过专利文献检索,对达拉他韦相关的中国专利申请情况进行了分析,重点解析原研公司百时美施贵宝在中国的专利布局,旨在为国内药物研发机构和制药企业在达拉他韦的后期开发、专利保护策略以及知识产权布局等方面提供有益的参考。 Daclatasvir is a medication used to treat hepatitis C. It stops hepatitis C virus( HCV) viral RNA replication and protein translation by directly inhibiting HCV protein NS5 A. In this paper,we analyzed the patent applications of daclatasvir in China,mainly focusing on the time distribution and legal status of the patent applications of Bristol-Myers Squibb,as well as other applications related to daclatasvir. This paper may provide some beneficial suggestions in terms of drug research and development and protection of patents to domestic medicine research institutions and pharmaceutical companies.
作者 蒋君好 邓萍
出处 《中国新药杂志》 CAS CSCD 北大核心 2018年第4期385-389,共5页 Chinese Journal of New Drugs
关键词 达拉他韦 丙型肝炎 病毒抑制剂 专利分析 NS5A daclatasvir hepatitis C virus (HCV) virus inhibitor patent analysis NS5 A
  • 相关文献

参考文献5

二级参考文献28

  • 1胡玉荣,哈斯额尔敦,十月.丙型肝炎的流行现状与预防[J].基层医学论坛,2006,10(2):178-179. 被引量:10
  • 2张福奎,贾继东.慢性丙型肝炎合并肝脂肪变的诊治[J].药品评价,2007,4(2):88-90. 被引量:3
  • 3PAWLOTSKY JM. Treatment of chronic hepatitis C: current and future[J]. Curr Top Microbiol Immunol, 2013, 369:321-342.
  • 4World Health Organization. Hepatitis C: fact sheet no.164. 2013.[EB/OL]. (2013-12-18) [2014-02-20]. http://www.who.int/mediacentre/factsheets/fs164/en/.
  • 5雷光宇.索非布韦激情引爆原料中间体[N]. 医药经济报, 2015-1-26(6).
  • 6LEE C,MA H,HANG J Q,et al. The hepatitis C virus NS5A inhibitor( BMS-790052 ) alters the subcellular localization of the NS5A. non-structural viral protein [J]. Virology,2011,414 (1) :10 -18.
  • 7BELEMA M, MEANWELL N A. Discovery of daclatasvir, apangenotypic hepatitis C virus NS5A replication complex inhibitor with potent clinical effect[ J]. J IVied Chem ,2014,57 (12) :5057 -5071.
  • 8BELEMA M, NGUYEN V N, BACHAND C, et al. Hepatitis C virus NS5A replication complex inhibitors:the discovery of daclatasvir [J]. J Med Chem,2014,57 ( 5 ) :2013 - 2032.
  • 9NELSON D R, COOPER J N, LALEZARI J P, et al. All-oral 12-week treatment with daclatasvir plus sofosbuvir in patients with hepatitis C virus genotype 3 infection:ALLY-3 phase HI study [J]. Hepatology,2015,61 (4) : 1127 - 1135.
  • 10Choo Q-L, Kuo G, Weiner AJ, et al.. Isolation of a cDNA clone derivedfrom a blood-borne non-A, non-B viral hepatitis genome[J]. Science, 1989,244: 359-362.

共引文献19

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部