SGLT2抑制剂代谢调控作用的相关研究进展

Recent progress of SGLT2 inhibitors in metabolic regulation

新型降糖药物钠-葡萄糖共转运蛋白2(SGLT2)抑制剂通过抑制肾脏对葡萄糖的重吸收,从而实现降低血糖的作用。近年来,SGLT2抑制剂在调控机体代谢中的作用已为研究所揭示。同时,SGLT2抑制剂对心血管保护作用也日渐得到关注。本文综述了SGLT2抑制剂在调控机体糖、脂代谢,改善2型糖尿病患者体重及胰岛素抵抗,调节机体肠促胰素水平,保护胰岛β细胞,保护心血管等方面的最新研究进展。

Sodium-glucose linked transporter 2（ SGLT2） inhibitors are a new class of approved oral anti-diabetic agents,which reduce plasma glucose levels via inhibiting the reabsorption of glucose by renal SGLT2 to promote glucose excretion. Recently,the role of SGLT2 inhibitors in metabolic regulation has been revealed.Meanwhile,increasing attention is being paid to the cardiovascular protection of SGLT2 inhibitors. This article briefly summarized the latest advances of SGLT2 inhibitors in regulations of glucose homeostasis and lipid metabolism,improvements of body weight and insulin resistance in type 2 diabetes patients,islets β cells protection,incretins secretion,and cardiovascular protection.