脑心通胶囊治疗糖尿病合并颈动脉粥样硬化疗效观察

The curative effect of Naoxintong Capsule in the treatment of diabetes with carotid atherosclerosis

目的:观察脑心通对糖尿病合并颈动脉粥样硬化的治疗作用。方法:64例糖尿病合并颈动脉粥样硬化患者,随机分成脑心通组与阿司匹林组,脑心通组32例给予脑心通治疗,阿司匹林组(ASP)32例予以阿司匹林治疗。两组患者连续治疗1年,治疗前后采用彩色多普勒超声观察颈动脉结构及血流状态,并测定颈动脉内膜-中层厚度(IMT)、血脂等指标及参数。结果:脑心通组患者颈动脉IMT显著变薄(P<0.05),血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)显著下降(P<0.01),而ASP组患者颈动脉IMT、血脂指标(TC、TG、LDLC)治疗前后无差异性(P>0.05)。治疗期间未见脑心通明显副反应。结论:脑心通可作为糖尿病合并颈动脉粥样硬化的一种有效而安全的药物广泛应用。

Objective： To investigate the therapeutic effect of Naoxintong on diabetic patients with carotid atherosclerosis.Methods： 64 patients with diabetes complicated with carotid atherosclerosis were randomly divided into Naoxintong group and aspirin group. 32 patients in Naoxintong group were treated with Naoxintong and 32 patients in aspirin group were treated with aspirin.Two groups with continuous therapy for 1 year,after and before treatment,two groups were examined with color Doppler ultrasonography on（carotid artery） intima-media thickness（IMT）,blood lipid and other parameters. Results： Naoxintong group：Carotid IMT was significantly thinner（P〈0. 05） and the levels of serum total cholesterol（TC）,triglyceride（TG） and low density lipoprotein cholesterol（LDL-C） were significantly decreased（P〈0. 01） after treatment. ASP group： There was no significant difference in the levels of carotid IMT and TC,TG and LDL-C before and after treatment（P〉0. 05）. There was no significant side effect during the treatment. Conclusion： Naoxintong can be used as an effective and safe drug for diabetes with carotid atherosclerosis.