不同给药途径治疗稽留流产的临床效果分析

Analysis on the clinical effect of different routes of medication in the treatment of missed abortion

目的评价米索前列醇不同的给药途径治疗稽留流产的临床效果。方法选取莆田学院附属医院2015年1月~2016年6月收治的80例稽留流产患者作为研究对象,随机分为试验组和对照组,每组各40例。试验组给予米非司酮150 mg口服联合米索前列醇片0.6 mg塞阴,对照组给予米非司酮150 mg口服联合米索前列醇片0.6 mg口服。观察比较两组患者的子宫收缩时间、服药后排胚时间、排胚后2 h出血量及完全流产率。结果试验组患者的子宫收缩时间及排胚时间明显早于对照组,差异有统计学意义(P<0.05);试验组排胚后2 h出血量明显少于对照组,差异有统计学意义(P<0.05)。试验组完全流产率为20.0%,高于对照组的5.0%,差异有统计学意义(P<0.05)。结论米非司酮联合米索前列醇塞阴治疗稽留流产的临床效果明显优于米非司酮联合米索前列醇口服,排胚后清宫率较低。

Objective Evaluation of clinical effect of Misoprostol on different routes of medication in the treatment of missed abortion.Methods 80 eases of patients with missed abortion from put/an college affiliated hospital from January 2015 to June 2016 were selected as the subjects,and randomly divided into the experimental group and the control group,40 eases in each group.The test group received 150 mg oral Mifepristone combined with Misoprostol 0.6 mg plug vagina.The control group received 150 mg oral Mifepristone combined with Misoprostol 0.6 mg oral.The uterine contrac- tion time,time of discharge of embryo after taking medicine,the amount of bleeding and the rate of complete abortion after 2 hours between the two groups were observed and compared.Results In the experimental group,the time of uter- ine contraction and the discharge time were significantly less than those in the control group,the difference was statisti- cally significant （P〈0.05）.The amount of bleeding in the experimental group was significiantly less than that in the con- trol group after 2 h,the difference was statistically significant （P〈0.05）.The complete abortion rate was 20.0% in the test group,higher than 5.0% in the control group,the difference was statistically significant （P〈0.05）.Conclusion Mifepristone combined Misoprostol plug vagina for missed abortion has better clinical efficacy than Mifepristone combined Misoprostol oral,which has the lower rate of embryos after discharge.