药物干预对晚期肿瘤合并抑郁状态患者生活质量的影响

Influence of drug intervention on the quality of life in patients with advanced tumor and depression

目的探讨药物干预对晚期肿瘤合并抑郁状态患者生活质量的影响。方法选择2012年4月~2016年4月在我院诊断治疗的晚期肿瘤合并标准抑郁状态的患者214例,采用随机数字表法将其分为实验组112例,对照组102例,对照组患者进行常规的抗肿瘤治疗,实验组在对照组治疗基础上,每日早、午饭后各予1片氟哌噻吨美利曲辛片治疗,>60岁的患者每日早饭后服用1片氟哌噻吨美利曲辛片。1、2、3、4周后再次用QOL量表进行评分。结果实验组患者第4周后数值高于第0组,差异有统计学意义(P<0.05),实验组患者治疗后QOL评分高于对照组,差异均有统计学意义(P<0.05),实验组的副作用高于对照组(P<0.05)。结论晚期肿瘤合并抑郁状态联合应用氟哌噻吨美利曲辛药物干预,可提高晚期肿瘤合并抑郁状态患者的生活质量,无明显不良反应,值得临床应用。

Objective To investigate the effect of drug intervention on quality of life in patients with advanced tumor and depression.Methods From April 2012 to April 2016,214 patients with advanced tumor complicated with standard depression were selected and randomly divided into experimental group（112 eases）,control group（102 cases）and control group （102cases）.The patients in the experimental group were treated with conventional anti-tumor therapy.on the basis of the treatment of the control group,the patients in the experimental group were treated with one tablet of Flupentixol Melitracen every morning and one tablet of Flupentixol Melitracen every day after lunch,and the patients〉60 years old were treated with 1 tablet of Flupentixol Melitracen every day after breakfast. After 1,2,3 and 4 weeks,QOL scale was used to score again.Results The QOL score of the experimental group at week 1-4 was significantly higher than that before treatment （P〈0.05）.The QOL score of the experimental group was higher than that of the control group（P〈O.05）, and the side effect of the experimental group was higher than that of the control group （P〈O.05）.Conclusion Drug intervention of Flupentixol Melitracen can improve QOL of patients with advanced tumor combined with depression,and without obvious adverse reactions,is worthy of clinical application.