醋酸甲地孕酮治疗子宫内膜癌的临床效果

Clinical effect of Megestrol Acetate in the treatment of endometrial carcinoma

目的探讨醋酸甲地孕酮治疗子宫内膜癌的临床效果。方法选择2016年7月~2017年7月我院收治的80例子宫内膜癌患者,遵循患者的个人意愿进行分组治疗。其中,39例患者选择常规治疗,设为对照组,另外41例子宫内膜癌患者设为观察组,选择在对照组的基础上应用醋酸甲地孕酮强化治疗。对比两组患者的治疗效果以及生活质量改善情况。结果经过治疗后,两组子宫内膜癌患者均出现不同程度的胃肠道反应,观察组患者的胃肠道反应发生率为9.76%,显著低于对照组的35.90%,差异有统计学意义(P<0.05)。观察组患者的复发率为7.32%,对照组为30.77%,两组比较,差异有统计学意义(P<0.05)。观察组患者治疗后的生活质量各项评分均高于对照组(P<0.05)。结论醋酸甲地孕酮在治疗子宫内膜癌患者中的临床价值确切,不仅能够减少患者的胃肠道反应、复发率,还可以显著提高子宫内膜癌患者的生活质量,在临床上的应用效果非常重要,值得进一步探讨研究。

Objective To investigate the clinical effect of Megestrol Acetate in the treatment of endometrial carcinoma. Methods From July 2016 to July 2017,80 patients with endometrial cancer in our hospital were treated.According to their personal will,they were grouped.Among them,39 patients were treated with routine therapy,and the rest 41 patients with endometrial carcinoma treated with Megestrol Acetate on the basis of the control group for intensification.Patients treated by routine therapy was classified into control group,and by intensified treatment was categorized into observation group.The therapeutic effect and improvement of quality of life between the two groups were compared.Results After treatment,patients with endometrial cancer in the two groups occurred with gastrointestinal reactions to some extent.The incidence of gastrointestinal reaction in the observation group was 9.76% ,significantly lower than that in the control group accounting for 35.90% with a statistical difference （P〈O.OS）.The recurrence rate was 7.32% in the observation group and 30.77% in the control group,which was displayed statistical significance after comparison （P〈0.05）.The scores of quality of life in the observation group were all higher than those in the control group （P〈0.05）.Conclusion Application of Megestrol Acetatein the treatment of endometrial cancer obtains a definite clinical value.It not only re- duces the patient＇s gastrointestinal reaction and recurrence rate,but also markedly improve the quality of life in endometrial cancer patients,which plays a vital role in clinical practice and is worthy of further study and exploration.