BRI1受体的胞内运输及其在油菜素甾醇信号转导中的作用

Subcellular Trafficking of BRI1 Receptors and Its Role in Brassinosteroids Signal Transduction

油菜素甾醇(brassinosteroids,BRs)作为一种重要的植物激素调控植物生长发育的诸多进程以及逆境胁迫响应,而其信号转导途径的研究也一直是植物生物学研究的热点之一。BRs信号的识别起始于BRI1(brassinosteroid insensitive 1)受体对BRs的感知,然后通过一系列下游信号组分进行转导实现对靶基因的表达调控。该文主要从细胞生物学的角度综述了新合成的BRI1通过内质网质量控制系统监控后运输到细胞膜上、BRI1的内吞作用和液泡运输、共受体BAK1(BRI1-associated kinase 1)影响BRI1的胞内运输以及BR信号的终止等内容,并探讨了今后的研究方向及待解决的问题。

Brassinosteroids（BRs） are a class of important phytohormones that control many processes during plant development and also responsible to stress. Thus, studies in BRs signal transduction are one of the hotspots in the field of plant biology. The BRI1（brassinosteroid insensitive 1） receptor perceives BRs signal to initiate signal transduction, which is subsequently propagated through a number of downstream components, resulting in transcriptional changes of BRs-responsive genes. From the perspective of cell biology, the aim of this review is to summarize recent advances on the following aspects：（1） newly synthesized BRI1 receptors trafficking to the plasma membrane after being monitored by endoplasmic reticulum quality control;（2） endocytosis and vacuolar trafficking of BRI1;（3） the co-receptor BAK1（BRI1-associated kinase 1）-mediated regulation of BRI1 trafficking;（4） termination of BR signaling, and highlight the open questions and potential research directions.