抗磷脂抗体、肿瘤与血栓相关关系

The Correlativity among Antiphospholipid Antibodies, Tumors and Thrombosis

抗磷脂抗体(antiphospholipid antibodies,a PL)作为自身抗体,在机体内能与多种磷脂类物质发生免疫反应,除了可以引起自身免疫性疾病外,抗磷脂抗体还可以引起如血栓形成等其他的病理反应。在肿瘤患者体内,抗磷脂抗体的检出率也较一般人群为高,而血栓也常常会伴随着肿瘤形成,进一步出现相应的临床症状。在抗磷脂抗体、肿瘤与血栓三者之间存在着一定的相互作用,但它们之间的联系并没有研究透彻。该文就近些年来在相关领域的研究进展作一综述,为更深入的研究提供一些方向与思路。

Antiphospholipid antibodies（a PL）, as aseries of autoantibodies, can react with numerous phospholipids substances in the human body. Despite causing autoimmune diseases, a PL can also cause thrombosis and other pathological reactions. It was found that the detection rate of a PL is higher in cancer patients than the general population. Moreover, tumor is often accompanied by thrombosis and can further cause related clinical symptoms. There are certain correlativity and interactions among a PL, tumors and thrombosis, nevertheless, the exact relationship remains obscure. This review aims to summarize and clarify the latest progressesin this field by focusing on the relevant studies in recent years. We think this review will provide some novel insights and directions for further researches.