噬菌体裂解酶作用机制及用于细菌感染治疗的研究进展

Mechanism and progress of the research on the treatment of bacterial infection with bacteriophage lysin

噬菌体裂解酶具有高效性、高稳定性、潜在广泛杀菌性和安全性,能特异性的杀灭细菌而且不容易使细菌产生耐药性。在有噬菌体存在的情况下,噬菌体侵入细菌并编码产生裂解酶,裂解酶在细菌内"自内裂解"细菌,在没有噬菌体存在的情况下,穴蛋白协助裂解酶"自外裂解"细菌。此外,本文还回顾了裂解酶对革兰阳性菌如耐甲氧西林金黄色葡萄球菌、化脓性链球菌,阴性菌如鲍曼不动杆菌、铜绿假单胞菌感染的治疗新进展。

Bacteriophage lysin is characterized by high stability,wide bactericidal activity and efficacy,and safty. It is able to lyse bacteria specifically and is not susceptible to bacterial resistance. In the presence of phage,phage infecting bacteria and coding for endolysin then it lyse the bacteria,In the absence of the phage,holin assists the endolysin lysis the bacteria from external. In addition,the research progress on the treatment of Gram-positive bacteria,such as methicillin-resistant Staphylococcus aureus,Streptococcus pyogenes,and Gram-negative bacteria,such as Acinetobacter baumannii and Pseudomonas aeruginosa,was also discussed in this paper.