靶向肿瘤干细胞的免疫疗法

Immunotherapy of targeting at tumor stem cells

由于肿瘤干细胞(TSCs)与肿瘤的发生﹑发展﹑转移﹑复发和耐药等有着密切关系,是肿瘤的根源细胞,意味着治愈肿瘤的关键途径可能在于根除TSCs。因传统的手术﹑化疗和放疗等对肿瘤治疗的方法无法杀死TSCs,容易导致肿瘤转移和复发,而靶向TSCs的免疫疗法已确定能杀伤TSCs,如靶向TSCs的表面抗原﹑T细胞靶向TSCs的应用和分化疗法等。

Tumor stem cells（ TSCs）,because of its close related to occurrence,development,metastasis,recurrence and drug resistance of tumor,are considered by research commnity as a root cell bank of the tumor. In other words,The key way to cure tumor may be to eradicate TSCs. The traditional surgery,chemotherapy and radiotherapy not only have few effect in killing TSCs,but result in recurrence and metastasis easily. However,TSCs can definitely killed by the immunotherapy targeting TSCs,for instance,targeting the surface antigens of TSCs＇,T cells targeting the TSCs,differentiation therapy and so on.