ESE-3转录因子与肿瘤发生

ESE-3 transcription factor and tumorigenesis

ESE-3属于ETS超家族的ESE亚家族,位于染色体11p12,广泛存在于细胞核内,属于转录调控因子,能够单独与其效应分子形成转录复合物,增强或抑制不同下游靶基因的转录。ESE-3在结肠癌、胰腺癌、前列腺癌和乳腺癌等多种肿瘤中表达出现异常,与多种恶性肿瘤的发生发展有重要关系。

ESE-3 belongs to the epithelium-specific ETS transcription factor subfamily of ETS（ E26） located in chromosome 11 p12. It belongs to the transcriptional regulation factor which forms transcription complexes with its effector molecules,enhancing or inhibiting transcription of different downstream target genes. The expression of ESE-3 is abnormal in many kinds of tumors,such as colon cancer,pancreatic cancer,prostate cancer,breast cancer and so on. It suggests that ESE-3 plays an important role on the pathogenesis of various tumors.