病原微生物诱导上皮间充质转化的相关研究进展

Microbial pathogens induce epithelial mesenchymal transition

上皮间充质转化是一种可参与调控胚胎发育、损伤愈合的复杂过程,并在肿瘤形成、发展和转移过程中发挥重要作用。多种诱导因素及转录因子可诱导、促进上皮细胞发生间充质样改变。随着肿瘤与细菌感染相关研究成为热点,细菌与上皮间充质转化的相关研究报道亦逐渐增多。细菌或病毒等病原微生物感染宿主细胞可通过多种不同机制上调参与上皮间充质转化的转录因子表达,减少上皮性标志物Ecadherin、细胞角蛋白等的表达,增强间充质性标志物Vimentin、N-cadherin等的表达,促进细胞迁移和侵袭,诱导上皮间充质转化的发生发展。本文对细菌和病毒等病原微生物诱导上皮间充质转化的相关研究进展作一综述。

Epithelial mesenchymal transition（EMT）is a complex molecular process that regulates the changes in cell morphology and function during embryogenesis and wound healing.EMT also plays a major role in tumorigenesis and metastatic progression.Multiple inducible factors and transcription factors can induce mesenchymal like transition.Microbial pathogens including bacteria and viruses upregulate a set of transcription factors involved in the EMT processes,decrease the expression of epithelial markers such as E-cadherin,and enhance the expression of mesenchymal markers such as Vimentin.This review aimed to summarize and highlight key evidences on the function and regulation of microbes in inducing EMT.