注射用头孢哌酮钠-舒巴坦钠治疗胆管感染的临床疗效

Clinical effect of cefoperazone sodium for injection sulbactam in treating biliary tract infection

目的探讨注射用头孢哌酮钠-舒巴坦钠治疗胆管感染的临床疗效。方法回顾性分析2016年1月—2017年1月于太原市中铁十二局集团中心医院收治的胆管感染患者90例,按照治疗方法不同分为对照组与研究组,各45例。对照组患者采用替硝唑治疗,研究组患者在对照组基础上给予注射用头孢哌酮钠-舒巴坦钠治疗,均持续治疗3~14 d。比较两组患者的临床疗效;就诊时、治疗后中性粒细胞计数及白细胞计数变化情况;肝功能指标(碱性磷酸酶、总胆红素、天冬氨酸氨基转移酶、丙氨酸氨基转移酶、直接胆红素);不良反应发生情况。结果研究组患者临床治疗总有效率高于对照组(P<0.05)。就诊时,两组患者中性粒细胞计数、白细胞计数比较,差异无统计学意义(P>0.05);治疗后,研究组患者中性粒细胞计数、白细胞计数低于对照组(P<0.05)。研究组患者碱性磷酸酶、总胆红素、天冬氨酸氨基转移酶、丙氨酸氨基转移酶、直接胆红素水平低于对照组(P<0.05)。两组患者均未出现明显不良反应。结论采用注射用头孢哌酮钠-舒巴坦钠治疗胆管感染的临床疗效确切,可有效改善患者肝功能,且安全性高。

Objective To investigate the clinical effect of cefoperazone sodium for injection sulbactam in treating biliary tract infection.Methods A total of 90 cases of biliary tract infection patients were selected from January 2016 to January 2017 in Taiyuan Iron 12 Bureau Group Central Hospital,which were divided into control group and study group according to different treatment methods,45 cases in each group.Control group was given tinidazole,study group was given cefoperazone sodium for injection sulbactam,both groups were treated for 3-14 days.The clinical effect,the number of neutrophils and white blood cell count before and after treatment,liver function indexes（alkaline phosphatase,total bilirubin,aspartate transaminase,alanine aminotransferase and direct bilirubin） and the incidence of adverse reactions were compared between the two groups.Results The total efficiency rate of study group was higher than control group（P〈0.05）.Before treatment,no significant differences of the number of neutrophils or white blood cell count was found between the two groups（P〉0.05）;after treatment,the number of neutrophils and white blood cell count of study group were lower than control group（P〈0.05）.The study group of alkaline phosphatase,total bilirubin,aspartate transaminase,alanine aminotransferase and direct bilirubin were lower than control group（P〈0.05）.No serious adverse reactions was found.Conclusion Cefoperazone sodium for injection sulbactam has an exactly clincial effect in treating biliary tract infection,it can effectively improve the liver function,and with high safety.