大叶小檗化学成分分析

Analysis of chemical constituents of Radex Berberis Amurensis

[目的]分析大叶小檗根的化学成分.[方法]采用各种色谱方法分离纯化,根据理化性质及波谱数据鉴定化合物的结构.[结果]从大叶小檗根的石油醚、二氯甲烷、醋酸乙酯萃取物中分离鉴定了11个单体化合物,分别为肉蔻豆酸(1)、菜油甾醇(2)、巴马汀(3)、β-谷甾醇(4)、豆甾醇(5)、小檗碱(6)、药根碱(7)、表小檗碱(8)、棕榈酸(9)、豆甾-4-烯-3-酮(10)及非洲防己碱(11).[结论]化合物1~5和8~11为首次从该植物中分离得到.

OBJECTIVE To analyze the chemical constituents of Radex Berberis Amurensis.METHODS Various chromatographic methods were applied for isolation and purification,physicochemical properties and spectral data were used to identify the structure of the compounds.RESULTS11 monomeric compounds were isolated from petroleum ether,dichloromethane and acetic ether extract of Radex Berberis Amurensis.They were identified as myristic acid（1）,campesterol（2）,palmatine（3）,β-sitosterol（4）,stigmasterol（5）,berberine（6）,jatrorrhizine（7）,epiberberine（8）,palmic acid（9）,stigma-4-ene-3-ketone（10）and columbamine（11）.CONCLUSION The compounds 1-5 and 8-11 were isolated from this plant for the first time.