细胞酸化在癫痫终止中的可能作用机制

Possible mechanism of cellular acidification in epilepsy termination

癫痫尤其是癫痫持续状态(SE),是一种严重危害人类健康的常见疾病。目前对癫痫发作和维持机制研究较多,但对癫痫如何终止却知之甚少。20世纪初已发现适度的细胞酸化可减缓或抑制癫痫患者的惊厥样发作。近年来许多研究证实,细胞酸化引起癫痫发作终止的机制与抑制性和兴奋性神经递质失衡、酸敏感性离子通道开放等机制密切相关。因此,与之相关的靶向药物和治疗手段将成为探索癫痫治疗的发展方向之一。

Epilepsy,especially the status epilepticus（SE）,is a kind of common disease which is seriously dangerous for people′s health.At present,many researchers are focusing on how the epilepsy seizures happen and maintain,but know little about how it stops.It was found that appropriate cell acidification played an important role in patients to slow down or inhibit epilepsy-like seizures in the early 20 th century.Recently,more and more researches have confirmed that cell acidification can induce the termination of epileptic seizure caused by disbalance of inhibitory and excitatory transmitters of nerve,opening of acid-sensing ion channels and so on.Therefore,these will likely become the new direction to explore new drugs or methods for epileptic treatment in the future.